A microRNA-21-responsive doxorubicin-releasing sticky-flare for synergistic anticancer with silencing of microRNA and chemotherapy

Combination treatment with doxorubicin and microRNA-21 inhibitor synergistically augments anticancer activity through upregulation of tumor suppressing genes.

Doxorubicin (DOX) is a key chemotherapeutic drug for cancer treatment. The antitumor mechanism of DOX is its action as a topoisomerase II poison by preventing DNA replication. Our study shows that DOX can be involved in epigenetic regulation of gene transcription through downregulation of DNA methyltransferase 1 (DNMT1) then reactivation of DNA methylation-silenced tumor suppressor genes in gli...

MicroRNA and Male Infertility: A Potential for Diagnosis

Silencing MicroRNA-155 Ameliorates

Co-inhibition of microRNA-10b and microRNA-21 exerts synergistic inhibition on the proliferation and invasion of human glioma cells.

MicroRNAs (miRNAs) are small non-coding RNAs that function as negative gene regulators. Alterations in the expression of miRNAs have been implicated in the pathogenesis and development of most human malignancies. Recent data indicate that microRNA-21 and microRNA-10b are significantly elevated in glioblastoma multiforme (GBM) suggesting their role...

Regulation of microRNA-mediated gene silencing by microRNA precursors

miRNAs are a class of about 1,000 noncoding RNAs that in mammals regulate about half of the protein-encoding genes by enhancing their degradation or preventing their translation1,2. After transcription, the long primary miRNA (pri-miRNA) transcripts are processed to 60to 80-nt precursor miRNAs (pre-miRNAs) and are subsequently cleaved to mature ~22-nt-long duplex RNAs3,4. With a few exceptions5...